Promethazine is metabolized with the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites showing up within the urine.
The drug is excreted largely during the urine, mostly as inactive metabolites and modest amounts of absolutely free and conjugated morphine. Negligible quantities of codeine and its metabolites are found in the feces.
Prescription drug abuse may be the intentional non-therapeutic utilization of a prescription drug, even once, for its worthwhile psychological or physiological outcomes.
Avoid the usage of Promethazine HCl and Codeine Phosphate Oral Option in adolescents twelve to 18 years of age who produce other possibility things that may increase their sensitivity to the respiratory depressant effects of codeine.
g., These with evidence of enhanced intracranial pressure or Mind tumors), Promethazine HCl and Codeine Phosphate Oral Option may cut down respiratory generate, as well as the resultant CO2 retention can even further improve intracranial stress. On top of that, opioids create adverse reactions that will obscure the clinical system of people with head accidents.
Parenteral drug abuse is commonly related to transmission of infectious diseases for instance hepatitis and HIV.
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Do not flush drugs down the rest room or pour them right into a drain Unless of course instructed to take action. Adequately discard this product when it really is expired or now not required. Talk to your pharmacist or regional squander disposal firm.
Just before getting this medication, convey to your medical professional or pharmacist In case you are allergic to any of its ingredients; or to opioid pain relievers (which include morphine); or Should you have every other allergy symptoms.
If adrenal insufficiency is diagnosed, address with physiologic substitution doses of corticosteroids. Wean the affected person off of the opioid to allow adrenal perform to recover and carry on corticosteroid procedure until finally adrenal function recovers. Other opioids could be tried using as some cases reported usage of a special opioid with no recurrence of adrenal insufficiency. The knowledge readily available won't recognize any distinct opioids as getting much more Promethazine codeine syrup prone to be connected to adrenal insufficiency.
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Do not flush remedies down the toilet or pour them into a drain unless instructed to do so. Effectively discard this merchandise when it really is expired or no longer wanted. Consult your pharmacist or regional squander disposal enterprise.
Opioid analgesics and antitussives, such as codeine, among the active components in Promethazine HCl and Codeine Phosphate Oral Alternative, really should not be Employed in clients with acute febrile sickness related to productive cough or in people with Continual respiratory sickness the place interference with power to crystal clear the tracheobronchial tree of secretions would have a deleterious impact on the affected person’s respiratory perform.
Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory melancholy, and sometimes death, in pediatric clients.